Aron B. Fisher, Brett Zani, Thomas Han, Chandra Dodia, Raffaele Melidone, Steven Keller. Decreased LPS-induced lung injury in pigs treated with a lung surfactant protein A-derived nonapeptide that inhibits peroxiredoxin 6 activity.

This study addressed the efficacy of a liposome-encapsulated 9 amino acid peptide (PIP-2) for the prevention or treatment of acute lung injury (ALI) +/- sepsis.

Female Yorkshire pigs were infused intravenously with lipopolysaccharide (LPS) + liposomes (untreated) or LPS + PIP-2 encapsulated in liposomes (treated). The porcine LPS-induced sepsis model was associated with moderate to severe lung pathophysiology compatible with ALI while treatment with PIP-2 markedly decreased lung injury, cardiovascular instability, and early sacrifice.

These results indicate that inhibition of ROS production via NOX1/2 has a beneficial effect in treating pigs with LPS-induced ALI plus or minus sepsis, suggesting a potential clinical role for PIP-2 in the treatment of ALI and/or sepsis in humans.