Bioengineering: Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development

Linnea Tscheuschner, Abraham R. Tzafriri. Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development. In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations. Over time, the realization has set […]

AALAS 2023: The Chinchilla Consortium: A Chinchilla Clinical Case Report Gold Mine

Amanda Darbyshire, Raphael Malbrue, Carmen Arsuaga, Andrea Osborne, Gina Dobek, Jiajie Jessica Xu, Misha Dunbar, Derek Fong, Lauren Habenicht, Michael Fink, Erica Feldman, Glenn Jackson, Leeza Birdwell, Erin Mitchell, Marie Ortega, Wendy Williams, Charlette Cain, Andie Moffitt, Misty Williams-Fritze, Chris Manuel. The Chinchilla Consortium: A Chinchilla Clinical Case Report Gold Mine. Chinchillas serve a unique […]

TCT 2023: Imaging-Based Evaluation and Differentiation of Vessel Preparation Technologies in a Porcine Model of Peripheral Artery Stenosis

Rami Tzafriri, PhD; Jay Budrewicz, ScM, LATG, SRT; Anna Maria Spognardi, BA; Eric A. Secemsky, MD. Imaging-Based Evaluation and Differentiation of Vessel Preparation Technologies in a Porcine Model of Peripheral Artery Stenosis.  PURPOSE: We evaluated surface modification effects of micro-incision and debulking preparation technologies on complex porcine peripheral in-stent restenosis lesions (ISRL). METHODS: Bilateral ISRL […]

TCT 2023: Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism

Rami Tzafriri, Lee-Jae Jack Guo, Benny Muraj, Peter Markham, Curtis Genstler, Joseph Czyscon, Christopher Piere, Christopher Knapp, Elazer R. Edelman. Ultrasound-enhanced clot thrombolysis in a porcine model of pulmonary embolism.  BACKGROUND: Catheter directed thrombolysis (CDT) delivering Tissue Plasminogen Activator (tPA) and Ultrasound (US) has shown clinical benefit, but the additional in vivo impact of US […]

New England Venture Summit, December 12-13, 2023, Boston, MA

Join CBSET at the New England Venture Summit , being held at the Hilton Boston/Dedham, 25 Allied Dr, Dedham, MA, December  12-13, 2023. The summit brings together investors and thought leaders from across the globe. Learn more about CBSET’s live streaming capabilities. Related CBSET Services: CBSET GLP Preclinical Services Localized/Targeted Drug Delivery  Computational Modeling of Local […]

Annals of Biomedical Engineering: Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons

Stratakos E, Antonini L, Poletti G, Berti F, Tzafriri AR, Petrini L, Pennati G. Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Drug-coated balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited, non-uniform coating transfer onto the arterial […]

SPS 2023: Maximizing Insights from Preclinical Safety Studies in the Context of Rising Costs and NHP Shortages

At the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, CBSET Study Director, Dr. Donald Hodges, discussed the history, regulatory framework and other factors influencing species selection in IND-enabling studies in a partner session organized by emka TECHNOLOGIES on Maximizing Insights from Animal Studies in the Context of Rising Costs and Shortages. Since 1937, the […]

CBSET Welcomes Efstathios Stratakos, Sept 1, 2023

CBSET welcomes ESR6 Efstathios Stratakos, an early-stage DECODE researcher. About Efstathios Stratakos Host: Politecnico di Milano In silico simulations at macro/meso scale of angioplasty with DCBs, focusing on the mechanical aspects at the balloon-vessel interface (WP3, WP4) Efstathios Stratakos received the Integrated Master’s Degree in Mechanical Engineering and Aeronautics from the University of Patras with […]

CBSET Welcomes Linnea Tscheuschner, Aug 27, 2023

CBSET welcomes ESR13 Linnea Tscheuschner, an early-stage DECODE researcher. About Linnea Tscheuschner Host: NKUA Influence of lesion complexity and coating formulation on local coating penetration and downstream embolization after treatment with drug coated balloons (WP3) Linnea Tscheuschner received a master’s degree in Life Science at the University of Hanover, Germany in 2022. Her master’s thesis […]